Inquiries in Science™
Inquiries in Science™ is a series of kit-based lab activities for high school students that actively engages them in learning essential science concepts through a guided-inquiry approach. Designed around the learning cycle of focus, explore, explain, and apply, each kit contains the necessary equipment and supplies for at least 30 students to perform the lab activities. Every kit also includes a comprehensive teacher’s manual with a reproducible student guide. Using the Inquiries in Science™: Discovering Nucleic Acids Kit as an example, we’ll show you how the kits implement the learning cycle through a guided-inquiry approach.

Focus
In Focus, the teacher helps students consider their prior knowledge about a topic and relate that knowledge to questions or problems in the context of a real-world scenario. The Focus of the Discovering Nucleic Acids Kit is to identify and model the steps of protein synthesis and to build an understanding of the effects of mutagens on organisms and their DNA. The teacher begins by reading the Focus with the class and initiates a discussion about how mutations and mutation-causing factors are a part of our everyday lives. Here’s a sample paragraph from the kit’s Focus section.
Deoxyribonucleic acid (DNA) is the genetic material in all living cells. DNA is arranged in the form of a double helix, which resembles a twisted ladder, with 2 complementary strands made up of nucleotide bases, sugars, and phosphates. The nucleotide bases found in DNA are adenine (A), cytosine (c), guanine (G), and thymine (T). The bases follow the base pairing rules discovered by DNA pioneers James Watson and Francis Crick: adenine and thymine always pair together, and guanine and cytosine always pair together.
Explore
In Explore, students gain hands-on experience relevant to the question or problem at hand. Using a guided-inquiry approach, the teacher leads students through investigations and models the scientific process. The Explore section of the Discovering Nucleic Acids Kit includes the 3 activities listed below.

  1. Students build models of DNA and replicate the process of protein synthesis. This is helpful as a review of the processes involved in protein synthesis.
  2. Students design and conduct an inquiry-based experiment in order to view the differing effects that mutations can have on proteins and the body.
  3. Students observe irradiated onion root tips and compare the mutated tips to normal onion root tips to see the effects of radiation on DNA.
Explain
In Explain, students develop and fine-tune their grasp of scientific concepts by analyzing, interpreting, and communicating data. The teacher acts as a facilitator and advisor, guiding students in their development and helping them confront misconceptions. Use the Explain section of the student guide as it best works for your class. You may read it together as a class or have students read it on their own. It can be assigned as a post-activity reading selection or as homework. Higher-level students might be able to answer the questions in the Apply section without reading the selection.

Apply
In Apply, students demonstrate their mastery of the concepts they have studied by applying what they have learned in the context of the original real-world question or problem. The teacher observes, assesses, and directs students’ progress toward the desired learning goals. Below are some example questions from the Apply section of the Discovering Nucleic Acids Kit Student Guide.

  1. Describe the structure of DNA. How are all strands of DNA the same? In what ways can DNA strands differ?
  2. What are some of the ways that you changed the DNA strand in Activity 2 in order to cause mutations? Were any of these disruptions similar to mutations that occur randomly in nature?
  3. How did the changes you made to the original DNA strand in Activity 2 affect the structure of the protein?
  4. What organelles are involved in protein synthesis?
Learn more
We hope you’ve gained a better understanding of the Inquiries in Science™ learning cycle and how you can put it to work in your classroom. To learn more about the Discovering Nucleic Acids Kit and other kits in the Inquires in Science™ series, visit us at www.carolina.com/Inquiries or contact Melissa Hodges at 800.334.5551, ext. 6355.