DNA Chips: Genes to Disease Lab Kit includes: Glass Slides Simulated Hybridization Solution 6 Simulated cDNA Solutions Instructions with Student Masters Pack of 30 Student Worksheets Refill Kit Includes: Simulated Hybridization Solution, 6 Simulated cDNA Solutions, and a pack of 30 Student Worksheets. Needed but not included: Hot Water Bath

"We ran this simulation in a 300-level genetics lab (college, not high school) last semester along with the supplementary math analysis that Dr. Laurie Heyer and Dr. Malcom Campbell (Davidson College) developed. It was a great success! Not only did the students enjoy the lab.... they [also] had significant gains in understanding. I really like this simulation!" Pamela A. Marshall, Ph.D. Assistant Professor of Integrated Natural Sciences Arizona State University, West Campus Glendale, AZ

DNA Chips: Genes to Disease Lab Kit Manual Other Biotechnology Manuals Carolina Biological has excellent manuals for your reference. The link will open a new browser window, so please disable popup blockers.

Advanced - For experienced high school and college classes; requires some technical skill.

• Simple microarray simulation
• No special equipment
• Comprehensive 2-to-4 day lesson plan
• 45-minute experiment
• Affordable lab option

This microarray simulation provides an inexpensive, hands-on lab to introduce students to microarrays, the complexities of gene expression, and the role of gene expression in cancer. Using simulated microarray technology, students compare the relative expression levels of 6 different genes in healthy lung cells and lung cancer cells.

Students then discuss the significance of the relative expression levels with respect to the genes' roles in causing cancer. Teacher's manual includes instructions for a bonus dry lab.