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Sickle-cell anemia is a classic classroom example of the overarching impact of a single point mutation in the human genetic code. The activity allows your students to further explore this human disease while they learn about protein structure, genetic inheritance, and human evolution. Because the lab requires no additional staining time and uses recombinant hemoglobin samples, it is one of the fastest, safest, and most realistic ways to bring protein electrophoresis into your classroom.
Intermediate—Easy to perform; requires some background knowledge.
Need a new way to help students make connections between the impact of mutations on protein structure? Or looking for labs that make real-world disease connections and link to larger concepts such as evolution? Either way, the Sickle-Cell Anemia Protein Electrophoresis Kit is perfect for your biology classroom. Students work with real-world samples, recombinant hemoglobin (poses zero pathogen risk), to conduct a genetic screen on a family and make determinations about the family's disease state. As a bonus, the kit works on agarose gels and does not require in-class staining, saving you money and time over typical protein electrophoresis kits. Both the 8-Station Kit and 4-Station Kit are designed for students working in groups of 2 to 4. Note: Sold only to schools and businesses.
