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HNPCC: Detecting Inherited Forms of Cancer GelGreen® Kit



Use heredity and biotechnology to explore colorectal cancer

  • Create a real-world connection
  • Construct accurate pedigrees across multiple generations
  • Perform genetic testing using gel electrophoresis
  • Explore the ethical dilemmas associated with genetic testing

Engaging students with a real-world impact
This lab provides students experience in drawing and interpreting a family pedigree in regards to a specific form of inherited colorectal cancer. The students then complete a DNA-based diagnostic test, using gel electrophoresis, of samples from the fictitious family to identify which members have inherited the cancer causing-mutation. After deciphering their results, students are tasked with taking on the role of a genetic counselor in charge of speaking with the family about the results.

Biotechnological revolution
Cancer diagnostics and treatments are on the front line of the biotechnological revolution. Researchers and clinicians are identifying new methods to identify the genes implicated in the cancer pathway and are applying the knowledge of those genes to develop targeted therapies. This laboratory exercise looks at genes linked to hereditary nonpolyposis colorectal cancer (HNPCC) and explores the connection between family medical history and testing for mutations in these genes.

Effortlessly incorporate into your classroom
This lab kit is designed to include all of the materials and background information you need to easily incorporate it into any course. The activity complements a study of the cell cycle and mitosis or a unit about genetic patterns of inheritance. Kit is designed for 32 students working in groups of 4 and includes 1-year access to digital resources that support 3-dimensional instruction. Requires 3 lab periods (45–60 min) and 1 discussion session to complete. The gel electrophoresis portion of the lab is done using GelGreen® DNA stain.

   This item is sold and shipped to schools and businesses only. Not available to individuals or residential addresses. For substitution suggestions, please call us at 800.334.5551 (8am to 8pm, ET, Monday-Friday).


Shipping Information or Purchase Restrictions
  • This item is sold and shipped to schools and businesses only. Not available to individuals or residential addresses. Visit our Login & Registration page to learn how to create a Login and link it to an approved school or business account.
What’s Included:
  • 8 DNA Ladder, 1 kb
  • 4 Normal Allele DNA (control), 25 µL
  • 4 Tumor DNA (control), 25 µL
  • 4 Heterozygote DNA (control), 25 µL
  • 4 Patient DNA (Marshall), 25 µL
  • 4 Patient DNA (Sara), 25 µL
  • 4 Patient DNA (Bob), 25 µL
  • 4 Patient DNA (Warren), 25 µL
  • 4 Patient DNA (Jane), 25 µL
  • 4 Patient DNA (Stan), 25 µL
  • 4 Patient DNA (Steven), 25 µL
  • 4 Patient DNA (Susan), 25 µL
  • 4 Patient DNA (Claire), 25 µL
  • 1 Agarose, 6 g
  • 1 TBE Buffer, 20x, 200 mL
  • 8 Staining Trays
  • 1 Sodium Chloride, 5 M, 8 mL
  • 1 GelGreen® Gel Stain, 100 µL
  • 16 Gloves
  • Carolina Science Online® Resources (1-year subscription)
  • 1 Teacher’s Manual with Reproducible Student Guide
Needed But Not Included:
  •  Container for Buffer
  •  Aluminum Foil
  •  Distilled or Deionized Water
  •  Graduated Cylinder, 1 L
  •  Flask, 1 L
  •  Horizontal Agarose Gel Electrophoresis System
  •  Power Supply for Electrophoresis System
  •  Microwave, Hot Plate, or Boiling Water Bath
  •  Water Bath, 60° C
  •  Hot Pad or Glove
  •  Micropipets (2 to 20 µL, 1 or 2 per gel being run)
  •  Micropipet Tips
  •  Permanent Marker
  •  Racks for Samples
  •  Blue-Light or UV Transilluminator
  •  Microcentrifuge (optional)
  •  Camera and Any Needed Filters (optional) 
Return Policy:

If for any reason you are not satisfied with this item, it is eligible for a return, exchange, refund, or credit up to 180 days from date of purchase. Restrictions may apply. Returns & Exchanges Policy.