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How Do Polygenic Risk Scores Stack Up? Kit

(in stock)


Product Details
A unique experience that teaches both graphing literacy and genetics

The How Do Polygenic Risk Scores Stack Up? Kit uses authentic data and graphical representations to address 2 central questions: How are traits, such as disease risk, distributed across a population? And how can identifying an individual's risk shape health care decision-making? Recent advances have led to models that combine the impact of genetic risk factors for an individual developing a particular disease into a single calculation known as a polygenic risk score (PRS). To help students understand how these models can affect health decisions, the activity employs 3-dimensional boxes to represent normal and skewed population curves, giving learners a visually impactful hands-on experience with the data. Students use these curves to examine polygenic risk scores and assess a person's risk for 2 different complex diseases. In addition to teaching essential data and graphing skills, the activity also highlights a weakness in current genomic research—lack of diversity—with the hope of equipping the next generation of researchers, health care workers, and consumers to address this critical issue.

Product Features

  • Designed for a class of 30 students and easily adaptable to larger classes.
  • Includes 30 unique boxes that stack and rotate to show 4 distinct data distributions.
  • Boxes are foldable for easy storage.
  • Visually impactful examples of normal and skewed distributions.
  • Discusses the need for diversity in current genomic research.

Time Requirements
One 90-minute block period or two 45-minute periods.

Learning Objectives

  • Analyze data on traits within a population to identify patterns within expressed traits.
  • Construct a model of trait distribution across a population and analyze data to determine where an individual lies within that distribution.
  • Discuss how relative diversity within a population sample can impact the clinical utility of an individual's polygenic risk score.
  • Classify a distribution graph as "normal" or "skewed."
  • Given a data set, build models that illustrate distribution across a population.
  • Explain what a polygenic risk score is and use it to assess an individual's genetic risk of developing a complex disease.
  • Describe the limitations of polygenic risk scores.


What’s Included:
  • 30 Printed Polygenic Risk Score Flat Boxes
  • 30 Polygenic Risk Score Personal Data Cards
  • 1 Carolina Science Online® Resources (1-year subscription)
  • 1 Teacher's Manual with Reproducible Student Guide
Needed But Not Included:
  • 30 Sticky Notes or Flags
Return Policy:

If for any reason you are not satisfied with this item, it is eligible for a return, exchange, refund, or credit up to 180 days from date of purchase. Restrictions may apply. Returns & Exchanges Policy.

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