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BioBuilder

BioBuilder

Carolina Biological Supply Company is proud to partner with BioBuilder, an award-winning team at MIT creating innovative STEM education focused on synthetic biology. BioBuilder approaches this exciting field with unique labs, connecting real-world questions in agriculture, medicine, biofuels, and environmental remediation with classroom content.

BioBuilder believes that authenticity generates engagement in STEM, and BioBuilder labs enhance existing science curricula. Spark critical thinking in your classroom by carrying out authentic investigations using the natural world to engineer and learn science.


Case Study: Collaboration Brings Advanced STEM Labs to High Schoolers

This is the story of how one Tennessee high school brought advanced opportunities to its students by integrating synthetic biology labs into its science curricula.

In 2019, the Eastman Foundation of Kingsport, Tennessee, approached the Kingsport schools about adding BioBuilder biology content to their high school STEM classes. “We were changing our philosophy in how we approach teaching and learning, shifting to more of a project-based approach,” explains Dr. Brian Cinnamon, chief academic officer for Kingsport schools. “So the opportunity to include BioBuilder content was a perfect way to do that.”


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BioBuilder® Eau That Smell Kit

molecular biology lab

AdvancedFor experienced high school and college classes; requires some technical skill.
Students learn microbiology techniques while modifying stinky bacteria into bacteria that smell like bananas. Use this lab to investigate the design and placement of promoters to determine gene expression. Collect class data to compare quantitative and qualitative results of microbial population growth dynamics.


Teacher Manual-Full Color
Teacher Manual-Black & White
Student Manual-Full Color
Student Manual Black & White
Overview Slides
Online Preview
Online Preview/Data Collection

BioBuilder® Golden Bread Transformation Kit

bacterial transformation

AdvancedFor experienced high school and college classes; requires some technical skill.
This lab focuses on a strain of baker's yeast, modified to produce ß-carotene, a nutrient we naturally obtain from eating specific vegetables. In the body, ß-carotene is converted to vitamin A, which is crucial for several biological functions. Investigate how one can possibly substitute standard baker's yeast, making it possible for users to bake vitamin A-enriched loaves of bread.


Teacher Manual-Full Color
Teacher Manual-Black & White
Student Manual-Full Color
Student Manual Black & White

BioBuilder® Golden Bread PCR

Polymerase Chain Reaction Sample

AdvancedFor experienced high school and college classes; requires some technical skill.
This biology lab explores the science, engineering, and bioethics of a yeast that's genetically modified to make a vitamin-enriched food. Lab activities include PCR, yeast transformation, codon shuffling, and quantitative analysis of data.


Teacher Manual-Full Color
Teacher Manual-Black & White
Student Manual-Full Color
Student Manual Black & White
Overview Slides

BioBuilder® iTune Device Kit

bioengineering

AdvancedFor experienced high school and college classes; requires some technical skill.
In this lab, students test different combinations of promoters and ribosome binding sites by looking at the beta-galactosidase enzyme output. Students learn about the lac operon, transcription, and translation while testing their genetic constructs. The simple lab procedure with spectrophotometry makes it possible for students to understand these challenging topics.


Teacher Manual-Full Color
Teacher Manual-Black & White
Student Manual-Full Color
Student Manual Black & White
Online Preview

BioBuilder® What a Colorful World Kit

bacterial transformation and chassis selection.

AdvancedFor experienced high school and college classes; requires some technical skill.
The molecular biology kit uses 2 bacterial cell types and 2 color-generating plasmids to teach DNA expression, inheritance, and sterile technique. The lab extends beyond classic transformation technique because it is put in context with the engineering concept of "chassis selection" when choosing the best host cell. Results are easy to analyze because the colors are visible to the naked eye.


Teacher Manual-Full Color
Teacher Manual-Black & White
Student Manual-Full Color
Student Manual Black & White
Overview Slides

BioBuilder® Guiding Light: Measuring and Analyzing Fluorescence Kit

BioBuilder® Guiding Light: Measuring and Analyzing Fluorescence Kit

AdvancedFor experienced high school and college classes; requires some technical skill.
In this simple yet impactful activity, students examine the relationship between fluorescence intensity and concentration of fluorescent molecules. They use a typical highlighting marker to create a standard curve, which gives them the ability to determine the concentration of fluorescent molecules in other samples.


Teacher Manual-Full Color

BioBuilder® Bioengineering for a Changing World Video Series

BioBuilder® Bioengineering for a Changing World Video Series

Grade 9–College
Looking for content to add to your synthetic biology class? This four-part digital video series dives into the DNA language that encodes cells and how that language can be deployed in scientifically sound ways to engineer solutions to challenges we read about in the news.






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