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Using the tools of biotechnology and the concept of DNA fingerprinting, students solve a forensic mystery. They cast agarose gels, load predigested DNA samples, and perform electrophoresis. Students then stain the gels and analyze the banding patterns of DNA collected from the suspects and the crime scene. Includes beautifully illustrated instructions as well as needed materials and equipment.

Exploring electrophoresis using forensic DNA evidence kit. Use evidence found in DNA fingerprint patterns to argue which suspect committed a crime.

PE: HS-LS3-2
Time Requirement: 2 45-minute Class Periods

SEP: Engaging in argument from evidence
CCC: Cause and Effect
DCI: LS3.B: Variation of Traits

Intermediate—Easy to perform; requires some background knowledge.

• Introduces students to the use of DNA analysis in forensic investigations
• Perform a technically simple, hands-on experiment in 45 minutes with 9-V batteries
• Discuss advanced topics of PCR and DNA fingerprinting

Solve a forensic mystery using the tools of biotechnology and the concept of DNA fingerprinting. Students cast agarose gels, load predigested DNA samples, and perform electrophoresis with one to three 9-V batteries. They stain the gels and analyze the banding patterns of DNA collected from the suspects and the crime scene. Includes beautifully illustrated instructions, free 1-year access to digital resources that support NGSS instruction, as well as needed materials and equipment to perform the lab twice. Materials are durable and reusable with replacement parts available.