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3D Molecular Designs. Discover how bacteria remember past viral infections and activate their CRISPR systems to search for and destroy the remembered virus' DNA—preventing infection. With this introduction to CRISPR biology, your students can build the bacteria's CRISPR array, detect the presence of viral double-stranded DNA, integrate a short fragment of this viral genome into the bacteria's CRISPR array, and express the CRISPR array to create the Cas9 proteins and the guide RNA.

3D Molecular Designs. Discover how bacteria remember past viral infections and activate their CRISPR systems to search for and destroy the remembered virus' DNA—preventing infection. This introduction to CRISPR biology will prepare your students to use Making the Cut with CRISPR-Cas9© Kit (item #216330) and understand how the Cas9 protein works. With the CRISPR Adaptive Immunity Kit's engaging foam pieces, your students can:

• Build the bacteria's CRISPR array, which includes Cas9, tracr, spacer and repeats
• Detect the presence of viral double-stranded DNA
• Integrate a short fragment of this viral genome into the bacteria's CRISPR array
• Express the CRISPR array to create the Cas9 proteins and the guide RNA

Kit equips 1 group of 4 students. Go to the 3D Molecular Designs website for additional resources: PDFs of Teacher Notes (an activity guide) to help you consider different ways to use the kit materials and additional resources to supplement or reinforce concepts presented in the classroom.