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Using a hypothetical scenario of an infant diagnosed with sickle cell disease, students are introduced to the process of translation by modeling the flow of genetic information on a region of the beta hemoglobin gene. Students model transcription and translation using unique magnetic nucleotide bases, develop their own protein translation model, and use clay to demonstrate the physiological effects of the sickle cell mutation. Kit equips a class of 32 students.

Product Details
Using a hypothetical scenario of an infant diagnosed with sickle cell disease, students are introduced to the process of translation by modeling the flow of genetic information on a region of the beta hemoglobin gene. In a series of investigations, students model transcription and translation using unique magnetic nucleotide bases, develop their own protein translation model, and use clay to demonstrate the physiological effects of the sickle cell mutation.

Have your students explore the question "Why did Baby Terra get sick?" through Mendelian and molecular modeling. Kit equips a class of 32 students working in groups of 4 and includes 1-year access to digital resources that support 3-dimensional instruction for NGSS.

Product Features

• Using manipulatives, model the flow of information through DNA translation and transcription of a region on the beta-hemoglobin gene, then apply the model to the mutation associated with sickle cell disease and its physiological effects.
• High school laboratory investigation with enough materials for 8 lab groups.
• Carolina Kits 3D®—Labs that use phenomena to support NGSS and 3-dimensional instruction.
• 1-year access to digital resources that support 3-dimensional instruction for NGSS included.

Performance Expectation(s)
HS-LS1-1

Time Requirements
Three 45-minute class periods.

Science and Engineering Practices
Developing and Using Models

Crosscutting Concepts
Systems and System Models
Structure and Function

Disciplinary Core Ideas
LS1.A: Structure and Function