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Using a hypothetical scenario of an infant diagnosed with sickle cell disease, students are introduced to the process of translation by modeling the flow of genetic information on a region of the beta hemoglobin gene. Students model transcription and translation using unique magnetic nucleotide bases, develop their own protein translation model, and use clay to demonstrate the physiological effects of the sickle cell mutation.
Students follow a hypothetical scenario of an infant, "Baby Terra," diagnosed with sickle cell disease. As they do, they are introduced to the process of translation by modeling the flow of genetic information on a region of the beta hemoglobin gene. In a series of investigations, students:
Have your students explore the question "Why did Baby Terra get sick?" through Mendelian and molecular modeling. The 1-Station Kit (item #211181) equips 1 group of up to 4 students. The 8-Station Kit (item #211183) equips a class of 32 students working in groups of 4. Both kits include 1-year access to digital resources that support 3-dimensional instruction for NGSS.